Effect of Statins in the Watch and Wait Phase of Chronic Lymphocytic Leukemia
Bibliographic record
Abstract
ABSTRACT Background It is an unclear how cholesterol‐lowering statin drugs affect progression of chronic lymphocytic leukemia (CLL). Methods Clinical records of 57 CLL patients were examined to determine how initiating statins in the “watch and wait” phase of management affected disease progression. Results After 6.4 ± 0.6 months, when average low‐density lipoprotein cholesterol levels had been lowered from 3.58 ± 0.11 mM to 2.1 ± 0.06 mM, blood levels of CLL cells and beta‐2‐microglobulin (β2M) increased significantly, accompanied by significant decreases in platelets. Following statin institution, rates of change of blood lymphocytes and β2M increased from 1.55 ± 0.39 × 10 6 to 3.4 ± 0.68 × 10 6 cells/mL/month ( n = 43) and 0.035 ± 0.011 to 0.055 ± 0.007 μg/mL/month ( n = 40), respectively. Conventional first‐line CLL treatment was ultimately required in 37 patients. Conclusions These observations suggest that statins as single agent do not slow and may even modestly stimulate progression of CLL.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".