Is unilateral approach under local anesthesia for parathyroidectomy feasible? A systematic review of literature
Bibliographic record
Abstract
INTRODUCTION: Primary hyperparathyroidism (PHPT) is a common endocrine disease especially in postmenopausal women and in older adults, with elevated parathyroid hormone (PTH) levels by parathyroid glands. The main symptoms of PHPT are hypercalcemia, often associated with hypercalciuria, urolithiasis and bone demineralization that results in osteopenia or osteoporosis and increases overall fracture risk. Parathyroidectomy is today the only definitive treatment for patients to prevent worsening of symptoms. Minimally invasive targeted approach for parathyroidectomy can be offered to patients with well-localized disease, and combined with intraoperative PTH monitoring, the success rate reaches 95-97%; with short operative time, low complications rates and decreased hospital costs. To date, minimally invasive parathyroidectomy (MIP) can be performed under local anesthesia and most patients can be discharged on the same day of surgery or the following morning. The aim of this article is to summarize the current evidence of MIP under local anesthesia and its clinical outcomes to assess the effectiveness and safety of this procedure. EVIDENCE ACQUISITION: May 2024. Inclusion criteria consisted in articles from any country written in English reporting MIP under local anesthesia related clinical outcomes in humans. RCTs, quasi-RCTs, cross-sectional studies, retrospective and prospective cohort studies, case-control studies were included. EVIDENCE SYNTHESIS: We identified 23 eligible studies that included 2470 adults (mostly female asymptomatic) with PHPT; follow-up duration varied from six months to 24 months. All studies were screened for assessments of quality based on Newcastle-Ottawa Scale and the risk of bias based on ROBIN-I of the included studies. The operative time, number of conversions to general anesthesia, hospital stay and complications was respectively: 43.86 minutes, with 114 conversions to general anesthesia, mean hospitalization time was 16.83±8.62 hours and complications reported in 71 patients. Previously of surgery, the abnormal parathyroid gland is localized using multiplexed ion beam imaging (MIBI) plus ultrasound (US) in 12 studies, only MIBI in three studies, thallium-technetium scan plus US in three studies, single-photon-emission computed tomography (SPECT) plus US in one study and a combination of MIBI, US, SPECT, CT and magnet resonance in one study. The mean preoperative value of PTH and serum calcium was 277.44 pg/mL and 11.49 mg/dL respectively; while the mean postoperative value of PTH and serum calcium was 46.18 pg/mL and 9.11 mg/dL respectively. At the definitive histology the most of pathology is adenoma with 542 cases reported, followed by hyperplasia with 35 cases and only 20 cases of carcinoma. CONCLUSIONS: Focused mini-invasive parathyroidectomy under local anesthesia, guided by positive preoperative localization exams and accurate laboratory data, could be a feasible and effective surgical technique to cure primary hyperparathyroidism, with reduced operative time, a small surgical incision, shorter hospitalization stay and a lower occurrence of postoperative complications.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.009 | 0.048 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.007 | 0.006 |
| Bibliometrics | 0.011 | 0.012 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.003 | 0.003 |
| Open science | 0.002 | 0.001 |
| Research integrity | 0.002 | 0.001 |
| Insufficient payload (model declined to judge) | 0.005 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".