Shock-Scattering Micro-Histotripsy-Aided Fine Needle Aspiration for Enhanced Biomarker Profiling and Cytopathology
Bibliographic record
Abstract
Core needle biopsy is the gold standard procedure for sampling tissues for pathology-based diagnostics. However, it produces significant tissue damage and may lead to undue pain and risk of complications such as infections. Alternatives such as fine needle aspiration and liquid biopsy have not yet achieved the same widespread utility owing to the limited abundance of cells and relevant biomarkers in extracted samples. Here we introduce a shock-scattering micro-histotripsy-aided fine needle aspiration technology which uses cavitation to liquefy nano-liter to micro-liter volumes to produce tissue homogenates with both intact and lysed cells. It permits not only conventional cytopathology with high success but sufficient high-quality tissue homogenates to enable reliable ancillary testing such as genetic biomarker profiling and even whole genome sequencing with improved quality compared to formalin-fixed samples. Our approach represents an advance in tissue diagnostics with orders of magnitude less damage than core-needle biopsy procedures.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.002 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".