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Record W4409760462 · doi:10.1016/j.jacig.2025.100489

Predicting airway hyperresponsiveness to methacholine in patients with atopic dermatitis

2025· article· en· W4409760462 on OpenAlexaff
Ruth P. Cusack, Anchalee Senavonge, Christiane E. Whetstone, Nadia Alsaji, Karen Howie, Caitlin Stevens, Jennifer Wattie, Lesley Wiltshire, Roma Sehmi, Paul M. O’Byrne, Hermenio Lima, Gail M. Gauvreau

Bibliographic record

VenueJournal of Allergy and Clinical Immunology Global · 2025
Typearticle
Languageen
FieldMedicine
TopicDermatology and Skin Diseases
Canadian institutionsMcMaster University
Fundersnot available
KeywordsMethacholineAirway hyperresponsivenessMedicineAtopic dermatitisDermatologyAsthmaAirwayBronchial hyperresponsivenessImmunologyInternal medicineAnesthesiaRespiratory diseaseLung

Abstract

fetched live from OpenAlex

Background: There are overlapping physiologic mechanisms between atopic dermatitis (AD) and asthma. However, predictive factors in development of airway hyperresponsiveness (AHR) in patients with AD are lacking. Objective: This study aimed to determine factors predictive of AHR in patients with AD without a history of asthma. Methods: We performed a cross-sectional study measuring methacholine AHR in 12 participants with AD without a history of asthma. The clinical data measured included AD onset and severity. In addition, skin biopsy sample scores, sputum eosinophil counts, blood eosinophil counts, total IgE levels, and spirometry findings were obtained and compared between subjects with and without methacholine AHR. Results: = .058]). Conclusion: /FVC (% predicted).

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.001
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.009
Threshold uncertainty score0.314

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.010
GPT teacher head0.321
Teacher spread0.310 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2025
Admission routes1
Has abstractyes

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