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The silent scream: Unraveling vagal nerve neuralgia; VANCOUVER syndrome and HeLPS

2025· review· en· W4409787406 on OpenAlexaboutno aff
Erfan Shahabinejad, Amirreza Shakoeizadeh, Mina Jafari, Nima Rafati, Behina Salarian, Farid Abbaspour, Florian Röser, Abdulrahman Albakr

Bibliographic record

VenueClinical Neurology and Neurosurgery · 2025
Typereview
Languageen
FieldMedicine
TopicTrigeminal Neuralgia and Treatments
Canadian institutionsnot available
Fundersnot available
KeywordsMedicineAnesthesia

Abstract

fetched live from OpenAlex

Cranial nerves are mechanically irritated by vascular compression in neurovascular compression syndromes. Vagus nerve neuralgia is one of the less prevalent types of Neurovascular Compression Syndromes. It can cause disorders like Hemilaryngopharyngeal Spasm (HeLPS) and Vagus Associated Neurogenic Cough (VANCOUVER syndrome). HeLPS presents with unilateral spasms of the throat and coughing, whereas VANCOUVER syndrome is typified by a chronic cough brought on by vascular encroachment on the rootlet of the vagus nerve. The diseases' clinical manifestations, diagnosis, differential diagnoses, and therapy approaches are discussed, emphasizing the role of microvascular decompression (MVD) in the case of conservative treatment failure. Due to vagus nerve neuralgia's similarities to other diseases, including psychiatric conditions and gastroesophageal reflux disease (GERD), it can be difficult to diagnose and treat. To make the best possible treatment decisions, the effectiveness of both conservative and surgical care modalities including MVD and medication is discussed. • HeLPS and VANCOUVER syndromes are rare vagal nerve neuralgias caused by vascular compression of the vagus rootlet. • Microvascular decompression may cure both syndromes; medications and botulinum toxin offer only partial relief. • High-resolution MRI identifies vagus nerve conflicts, but imaging findings must match clinical symptoms. • VANCOUVER syndrome causes a tickling sensation and chronic cough, unresponsive to standard therapies like antibiotics or anti-reflux therapy. • Untreated, these syndromes impair quality of life and may cause syncope, incontinence, or airway emergencies.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.002
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMeta-epidemiology (narrow)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.950
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.002
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0030.001
Bibliometrics0.0000.000
Science and technology studies0.0000.001
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0010.002
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.061
GPT teacher head0.387
Teacher spread0.325 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

Study designNot applicable
Domainnot available
GenreReview

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations1
Published2025
Admission routes1
Has abstractyes

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