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Record W4409795020 · doi:10.61091/jcmcc127b-384

Multi-objective genetic algorithm-based molecular screening of exosomes and modeling of their relationship with gene probes

2025· article· en· W4409795020 on OpenAlexvenueno aff

Bibliographic record

VenueJournal of Combinatorial Mathematics and Combinatorial Computing · 2025
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicExtracellular vesicles in disease
Canadian institutionsnot available
FundersNatural Science Foundation of Shandong Province
KeywordsMicrovesiclesComputational biologyGenetic algorithmGeneMolecular modelAlgorithmComputer scienceBiologyGeneticsMachine learningBiochemistrymicroRNA

Abstract

fetched live from OpenAlex

In the context of artificial intelligence technology, the current academic research on the relationship between exosome molecular screening and the role of gene probes is relatively weak.Accordingly, this paper formulates a modeling study of exosome molecule screening and its relationship with gene probes under the framework of multi-objective genetic algorithm.The multi-objective genetic algorithm is applied to realize the screening of secretory body molecules, and after the completion of the screening work, the mechanism of the role between exosome molecules and gene probes is investigated by constructing a regression model, and the above theoretical knowledge is applied to empirically analyze the research scheme of this paper.The regression coefficients of exosome molecules and gene probes showed significant correlation at 0.05 level, indicating that the mechanism of action between the two is monotonically increasing, which well reveals the influence of exosome molecules on gene probes.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.002
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Simulation or modeling · Consensus signal: Simulation or modeling
GenreCandidate signal: Empirical · Consensus signal: none
Teacher disagreement score0.015
Threshold uncertainty score0.029

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0010.002
Meta-epidemiology (narrow)0.0010.001
Meta-epidemiology (broad)0.0010.001
Bibliometrics0.0010.001
Science and technology studies0.0010.001
Scholarly communication0.0010.001
Open science0.0010.001
Research integrity0.0020.001
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.013
GPT teacher head0.253
Teacher spread0.240 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designSimulation or modeling
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2025
Admission routes1
Has abstractno

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