Oscillation cessation due to removal of Na+ current restored by external noise stimulation
Bibliographic record
Abstract
In this study, a complete two-dimensional anatomical model of the rabbit heart was constructed by Zhang et al.The positive effects of external noise stimulation on cardiac pacemaking and conduction have been studied using computer simulations.Our results show that: 1) the slower pacemaking rate or even oscillation cessation, which is induced by the removal of Na i from the sinoatrial node or a decrease in the active sinoatrial node cell population, can be recovered by adding external noise.2) Compared to the effect of Na i removal alone, the combined effect of Na i and cell death had a greater impact on slowing down the pacemaking rate.These phenomena indicate that external stimuli play an important role in controlling the initiation and conduction of sinoatrial node pacemaker activity, and that the aging heart may experience obstruction of sinus node conduction and even sudden cardiac death due to decreased cell membrane Na i or partial myocardial cell death.Our results provide insights into the intrinsic mechanisms underlying electroshock healing in some heart diseases.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".