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Record W4409825137 · doi:10.3389/fpsyg.2025.1559158

Sexual orientation is associated with 2D:4D finger length ratios in both sexes: an updated and expanded meta-analysis

2025· review· en· W4409825137 on OpenAlexaff
Ashlyn Swift‐Gallant, Toe Aung, Stephanie Salia, S. Marc Breedlove, David A. Puts

Bibliographic record

VenueFrontiers in Psychology · 2025
Typereview
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicSexual Differentiation and Disorders
Canadian institutionsMemorial University of Newfoundland
Fundersnot available
KeywordsMeta-analysisSexual orientationPsychologyOrientation (vector space)Cognitive psychologySocial psychologyMathematicsGeometryMedicine

Abstract

fetched live from OpenAlex

The ratio of the lengths of the 2nd and 4th fingers (2D:4D) is a putative marker for prenatal gonadal hormone signaling and has been linked to human sexual orientation. Although 2D:4D is consistently found to be lower in males than females, the association with sexual orientation is variable across studies, with one meta-analysis finding lower (more masculine) digit ratios in lesbians than heterosexual females, but no overall association in males. However, this previous meta-analysis considered neither unpublished datasets nor bisexual individuals separately from homosexual and heterosexual individuals. Moreover, 17 datasets examining relationships between 2D:4D and sexual orientation have been published since that time, and we located an additional 11 unpublished datasets. We therefore conducted an updated and expanded meta-analysis comprising 51 studies, including 44 male and 34 female datasets, totaling 227,648 participants. This meta-analysis also explored whether 2D:4D differed between heterosexual and bisexual and/or non-exclusive individuals in both sexes. Results indicate lower (more male-typical) digit ratios in homosexual women (right hand g = 0.26, left hand g = 0.16; both adjusted following trim-and-fill), and higher (more female-typical) ratios in homosexual men (right hand g = −0.17, left hand g = −0.20; both adjusted) compared to heterosexual same-sex counterparts. Moderator analyses do not support publication bias for females. For males, positive findings were more likely to be published, but robustness tests, including trim-and-fill and leave-one-out, support the findings’ robustness. No significant differences were observed in 2D:4D between male or female bisexual and heterosexual individuals. These findings are consistent with evidence that prenatal androgens increase attraction to females and/or that prenatal estrogens increase attraction to males.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMeta-epidemiology (narrow)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.637
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0020.000
Bibliometrics0.0010.001
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0010.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.045
GPT teacher head0.367
Teacher spread0.322 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

Study designNot applicable
Domainnot available
GenreReview

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations5
Published2025
Admission routes1
Has abstractyes

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