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Record W4409828937 · doi:10.1016/j.focha.2025.100992

Rwandan Coffee arabica has caffeine increasing with altitude, but undetectable phytomelatonin

2025· article· en· W4409828937 on OpenAlexaboutno aff
James Rurangwa, Francoise M. Twambaze, Védaste Kagisha, Abdullateef Isiaka Alagbonsi

Bibliographic record

VenueFood Chemistry Advances · 2025
Typearticle
Languageen
FieldMedicine
TopicCoffee research and impacts
Canadian institutionsnot available
Fundersnot available
KeywordsCaffeineArabica coffeeAltitude (triangle)Traditional medicineHorticultureBiologyMedicineInternal medicineMathematics

Abstract

fetched live from OpenAlex

• Rwandan C. arabica at high altitude had more caffeine than at lower altitudes. • TLC, GC–MS, and HP-LC detected no melatonin in Rwandan C. arabica . • Melatonin products from Belgium failed the quality assessment test. Altitude affects plants’ constituents. The presence of caffeine and melatonin in many plants, including C. arabica, has been widely reported. However, a possible variation of their quantity in Rwandan C. arabica samples across different altitudinal locations is not yet known. This study sought to provide this information. C. arabica samples from Kayonza, Ruhango, Gakenke, Gatsibo, Nyagatare, and Karongi districts, covering different altitude ranges in Rwanda, were obtained from the National Agriculture Export Development Board (NAEB). Analytical techniques like Thin-Layer Chromatography (TLC), High-Performance Liquid Chromatography (HPLC), and Gas Chromatography-Mass Spectrometry (GC–MS) were used. C. arabica samples from higher altitudes yielded higher caffeine content, while instant coffee samples showed a broad caffeine range. However, all the techniques detected no phytomelatonin in the C. arabica samples collected from different altitudinal locations in Rwanda following two extraction methods, even though melatonin supplements from pharmaceutical outlets manufactured in the USA (110 %), Canada (106 %), Denmark (102 %), and Belgium (2.8 %) had detectable melatonin. Rwandan C. arabica has no phytomelatonin but shows increased caffeine content with increasing locational altitude. Further studies to analyze the precursors and enzymes involved in the phytomelatonin biosynthetic pathways in plants are needed to unravel this mystery.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.071
Threshold uncertainty score0.738

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.014
GPT teacher head0.281
Teacher spread0.266 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations1
Published2025
Admission routes1
Has abstractyes

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