Functional thalamocortical innervation of VIP- and SST-expressing GABAergic interneurons in mouse barrel cortex
Bibliographic record
Abstract
In sensory cortices, conscious perception of stimuli involves a complex interplay of excitatory and inhibitory circuits. The subcortical source of sensory information is the thalamus, which in the whisker system houses (1) the "lemniscal" ventral posteromedial nucleus (VPM) and (2) the "paralemniscal" medial part of the posterior nucleus (POm). How much these two complementary inputs can drive feedforward inhibition in cortical layers by synapsing on GABAergic neurons is still incompletely understood. Here, we used optogenetics to study the incidence of VPM and POm projections to vasoactive intestinal polypeptide (VIP)- and somatostatin (SST)-expressing interneurons in barrel cortex. By using sensitive stimulation and recording methods, we show that VIP and SST neurons receive an extensive input, largely independent of laminar location or various cellular properties. Thus, thalamus-mediated feedforward inhibition is implemented in the circuit motifs of probably all VIP and SST interneurons, which they might differentially use, dependent on specific whisking behaviors.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".