Review 5: "Single-dose VSV-Sudan Virus Vaccine Protects from Lethal Sudan Virus Infection within One Week: A Challenge Study in Macaques"
Bibliographic record
Abstract
The authors developed a recombinant VSV-Sudan virus glycoprotein (VSV-SUDV-G) vaccine, administering it intramuscularly to Cynomolgus macaques, and conducted challenge studies 28 days and one week after vaccination.They found that all vaccinated macaques were protected following a challenge with a lethal dose of SUDV.In contrast, both VSV-EBOV-vaccinated and unvaccinated control animals succumbed to the disease within a week after the challenge.Vaccinated animals showed no significant histopathological lesions in the lymph nodes, spleen, liver, or lungs, except for lymphoid hyperplasia and sinus histiocytosis in the spleen and peripheral lymph nodes.All macaques vaccinated with VSV-SUDV-G did not show cytokine storm profiles in the blood and lungs.The VSV-SUDV-G vaccine induced a comparable level of SUDV G protein-specific antibodies within two weeks and significantly increased the antibody titer two weeks after the SUDV challenge.Neutralizing antibodies against SUDV were induced more effectively in the D-28 group of macaques on the challenge day.The authors also examined the antibody Fc effector functions, such as antibody-dependent cellular phagocytosis (ADCP), antibody-dependent neutrophil phagocytosis (ADNP), and antibody-dependent complement deposition (ADCD).On the day of vaccination and thereafter, these functions increased in the macaque groups vaccinated with VSV-SUDV-G, whether 28 days or 7 days prior to the SUDV challenge.The results suggested that these antibody functions play a role in protecting the immunized macaques.However, the VSV-EBOV vaccinated macaques died despite having elevated ADCP levels on the day of the challenge, indicating that the SUDV challenge enhanced the significant antibody functionality of the SUDV G antigen.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.003 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.002 | 0.001 |
| Bibliometrics | 0.003 | 0.003 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.002 | 0.002 |
| Open science | 0.002 | 0.001 |
| Research integrity | 0.002 | 0.002 |
| Insufficient payload (model declined to judge) | 0.007 | 0.002 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".