Molecular entities for the anti-melanoma effect of Solanum nigrum
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
Prognosis for advanced and metastatic melanoma remains poor despite low incidence rate and early diagnosis. A significant number of melanoma patients use complementary and alternative medicines during their normal treatments in anticipating improving therapeutic efficacy. Solanum nigrum shows effective inhibitory activity against melanoma cells compared to Hedyotis diffusa, Scutellaria barbata, and Lobelia chinensis. Therefore, it is of interest to explore the anti-melanoma mechanism of S. nigrum. Our data show that three unique melanoma-related gene targets (CYP3A4, GBA2 and PTK6) for two unique active ingredients (diosgenin and solanocapsine) present in S. nigrum have potential role.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it