Clinical Manifestations and Therapeutic Management of Chondrodermatitis Nodularis Helicis: A Systematic Review
Bibliographic record
Abstract
To the Editor, Chondrodermatitis nodularis helicis (CNH) is a benign, inflammatory condition of the ear, typically presenting as a painful, solitary nodule on the helix or antihelix, often with scaling or crusting. 1It primarily affects individuals aged 50 to 80, though its incidence and prevalence are unclear. 2Trauma, actinic damage, cold exposure, collagen defects, and autoimmune diseases may contribute to the pathogenesis. 3This systematic review aims to provide a summary of reported cases of CNH, highlighting its clinical manifestations and therapeutic approaches.The study protocol was preregistered on PROSPERO (CRD42024561941) and conducted in accordance with PRISMA guidelines. 4MEDLINE and Embase databases were systematically searched from inception (1946) to June 25, 2024, using the keywords "chondrodermatitis nodularis helicis" OR "chondrodermatitis nodularis chronica helicis."Case reports, series, and observational studies with CNH diagnoses were included without language or geographic restrictions.Study quality was evaluated using the Oxford Centre for Evidence-Based Medicine criteria.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.003 | 0.001 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".