Chemical modification of sialylated oligosaccharides to functionalize nanostructured lipid carriers: exploring two different strategies
Bibliographic record
Abstract
-acetyl-neuraminic acid (Neu5Ac), a major carbohydrate involved in many cellular functions. 6'- and 3'-Sialyllactose were enzymatically produced and directly functionalized on their reducing ends using either oxime ligation or reductive amination. In the first strategy, thiol-modified oligosaccharides were grafted onto maleimide-decorated NLCs, and the second strategy focused on incorporating sialylated glycolipids into the formulation. Both methods successfully produced stable and monodisperse nanoparticles with sizes ranging from 60 to 100 nm. The functionalization efficiency (46 to 86%) was assessed by quantifying Neu5Ac present at the particle surface. The grafting approach yielded safe nanoparticles that show potential for use in anti-adhesive therapies against pathogens, such as the influenza viruses. However, their effectiveness needs to be optimized by further increasing carbohydrate density on the nanoparticle surface.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".