Possible side effects of hormonal castration in a dog
Bibliographic record
Abstract
INTRODUCTION: A young, healthy male Labrador developed regurgitation, diarrhea, and decreased general condition after hormonal castration using a deslorelin implant (Suprelorin®) and concurrent cyproterone acetate injection. The gastrointestinal symptoms improved with symptomatic treatment, but lethargy persisted. The cause of the initial gastrointestinal symptoms is suspected to be impairment of the hypothalamic-pituitary-adrenal axis by the injected cyproterone acetate. Cyproterone acetate has a known glucocorticoid effect and inhibits the hypothalamic-pituitary-adrenal axis like other progestogens. Low-dose (0,1 mg/kg once daily) and high-dose (1 mg/kg once daily) prednisolone therapy led to a slight improvement in the general condition. Seven weeks after the cyproterone acetate injection, the dog was noticeably more active, but only after the surgical removal of the deslorelin implant did the owner considered the dog «back to his old self.« This suggests that the dog's reduced general condition was a side effect of the hormonal neutering. Twenty-one weeks after the deslorelin implant application and cyproterone acetate injection, and fourteen weeks after the last prednisolone administration, the adrenal glands responded normally in the ACTH stimulation test. One year later, the owner describes the dog as healthy without any gastrointestinal symptoms since then.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".