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Record W4410019332 · doi:10.1038/s41586-025-08888-1

Adversarial testing of global neuronal workspace and integrated information theories of consciousness

2025· article· en· W4410019332 on OpenAlexaff
Oscar Ferrante, Urszula Górska, Simon Henin, Rony Hirschhorn, Aya Khalaf, Alex Lepauvre, Ling Liu, David Richter, Yamil Vidal, Niccolò Bonacchi, Tanya Brown, Praveen Sripad, Marcelo Armendáriz, Katarina Bendtz, Tara Ghafari, Dorottya Hetenyi, Jay Jeschke, Csaba Kozma, David Mazumder, Stephanie Montenegro, Alia Seedat, Abdelrahman Sharafeldin, S.-n. Yang, Sylvain Baillet, David J. Chalmers, Radoslaw Martin Cichy, Francis T. Fallon, Theofanis I. Panagiotaropoulos, Hal Blumenfeld, Floris P. de Lange, Sasha Devore, Ole Jensen, Gabriel Kreiman, Huan Luo, Mélanie Boly, Stanislas Dehaene, Christof Koch, Giulio Tononi, Michael Pitts, Liad Mudrik, Lucía Melloni

Bibliographic record

VenueNature · 2025
Typearticle
Languageen
FieldNeuroscience
TopicFunctional Brain Connectivity Studies
Canadian institutionsMcGill UniversityMontreal Neurological Institute and Hospital
FundersNational Institute of General Medical Sciences
KeywordsConsciousnessPsychologyFunctional magnetic resonance imagingCognitive psychologyCognitive scienceNeuroscienceElectromagnetic theories of consciousnessStimulus (psychology)MagnetoencephalographyVisual cortexPrefrontal cortexCognitionElectroencephalography

Abstract

fetched live from OpenAlex

Abstract Different theories explain how subjective experience arises from brain activity 1,2 . These theories have independently accrued evidence, but have not been directly compared 3 . Here we present an open science adversarial collaboration directly juxtaposing integrated information theory (IIT) 4,5 and global neuronal workspace theory (GNWT) 6–10 via a theory-neutral consortium 11–13 . The theory proponents and the consortium developed and preregistered the experimental design, divergent predictions, expected outcomes and interpretation thereof 12 . Human participants ( n = 256) viewed suprathreshold stimuli for variable durations while neural activity was measured with functional magnetic resonance imaging, magnetoencephalography and intracranial electroencephalography. We found information about conscious content in visual, ventrotemporal and inferior frontal cortex, with sustained responses in occipital and lateral temporal cortex reflecting stimulus duration, and content-specific synchronization between frontal and early visual areas. These results align with some predictions of IIT and GNWT, while substantially challenging key tenets of both theories. For IIT, a lack of sustained synchronization within the posterior cortex contradicts the claim that network connectivity specifies consciousness. GNWT is challenged by the general lack of ignition at stimulus offset and limited representation of certain conscious dimensions in the prefrontal cortex. These challenges extend to other theories of consciousness that share some of the predictions tested here 14–17 . Beyond challenging the theories, we present an alternative approach to advance cognitive neuroscience through principled, theory-driven, collaborative research and highlight the need for a quantitative framework for systematic theory testing and building.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.026
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMetaresearch
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Theoretical or conceptual · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.711
Threshold uncertainty score0.983

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.026
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.001
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.009
GPT teacher head0.254
Teacher spread0.246 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

Study designTheoretical or conceptual
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations86
Published2025
Admission routes1
Has abstractyes

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