Peripheral polyneuropathy secondary to nitrofurantoin administration in an adult cat.
Bibliographic record
Abstract
A 6-year-old castrated male domestic shorthair cat was referred because of a 5-day history of walking with a crouched hindlimb stance. Before referral, the cat had been recovering from perineal urethrostomy surgery, preceded by 6 wk of recurrent urinary tract infections, with 3 urinary blockages during that interval. The cat was being managed on nitrofurantoin (4 mg/kg, q8h), prescribed by the referring veterinarian and administered for only 1 d before the perineal urethrostomy surgery. Two days after the nitrofurantoin was restarted, the cat began displaying the crouched hindlimb stance. At the time of presentation for the crouched hindlimb stance, the cat had been administered nitrofurantoin (4 mg/kg, q8h) for a total of 6 d (1 d before the surgery and 5 d at home in between the 2 veterinary visits; however, the medication was not administered in hospital during either visit). Ambulatory paraparesis with no ataxia, decreased patellar reflexes, and decreased medial (digit 2) withdrawal reflexes were present in both hind limbs, consistent with a peripheral polyneuropathy affecting the femoral nerves. Computed tomographic imaging of the thoracic and lumbar spine showed no abnormalities compatible with the clinical signs. A presumptive diagnosis of peripheral polyneuropathy secondary to nitrofurantoin administration was made. Key clinical message: Although peripheral polyneuropathy is a reported side effect of nitrofurantoin, there are only isolated reports of its occurrence in humans and, to the authors' knowledge, no reported cases in companion animals. This case report focuses on the minimally reported neurologic side effects associated with nitrofurantoin administration in companion animals.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.000 | 0.001 |
| Research integrity | 0.002 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".