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Record W4410196832 · doi:10.1016/j.hpb.2025.03.056

Challenging paradigms: utilizing pancreatic cancer organoids to advance personalized medicine

2025· article· en· W4410196832 on OpenAlexaff
James O. Price, F.S. Vizeacoumar, Omar Abuhussein, Vincent Maranda, Yi Zhang, Hiroyuki Adachi, Liliia Kyrylenko, Aline Rangel‐Pozzo, Hang Dong, Ling Gong, Pravin S. Walke, Ashtalakshmi Ganapathysamy, Connor Denomy, Tanya Freywald, Ravinder Dahiya, Hussain Elhasasna, Anurag Saxena, Jeff Patrick Vizeacoumar, Hiten D. Patel, Karthick Rajamanickam, Kevin A. Nguyen, Deíse Moura de Oliveira, Mary Lazell-Wright, Amit Aggarwal, Jie Xu, Nuran Allı, Érika Prando Munhoz, Peng Gao, John M. Salsman, Divya Dahiya, Carlos G. Lopez, Pierre Thibault, Prama Pallavi, Felix Rückert, Michael Levin, Graham Dellaire, Nicholas Jette, John M. Shaw, G. Groot, A. Krishnan, Samrein B. M. Ahmed, Christopher H. Eskiw, Khaled Barakat, Yuliang Wu, Ronald A. DePinho, Shutao Mai, Yongjun Yu, John Wong, Andrew Freywald, Franco J. Vizeacoumar

Bibliographic record

VenueHPB · 2025
Typearticle
Languageen
FieldMedicine
TopicPancreatic and Hepatic Oncology Research
Canadian institutionsUniversity of Saskatchewan
Fundersnot available
KeywordsMedicineOrganoidPersonalized medicinePancreatic cancerPrecision medicineCancerComputational biologyInternal medicineOncologyBioinformaticsPathologyNeuroscience

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.001
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesInsufficient payload (model declined to judge)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.471
Threshold uncertainty score0.999

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0000.001
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0020.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.045
GPT teacher head0.398
Teacher spread0.353 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2025
Admission routes1
Has abstractno

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Same venueHPBSame topicPancreatic and Hepatic Oncology ResearchFrench-language works237,207