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Record W4410230280 · doi:10.1016/j.ocarto.2025.100622

MonitOring the health trajectory of patients with kNee osteoarthritis referred for orthopaedic opinion: Protocol for the MOTION parallel cohort-implementation study

2025· article· en· W4410230280 on OpenAlexafffund
Christian J. Barton, Michelle M. Dowsey, Anne Smith, Ilana N. Ackerman, Zanfina Ademi, Samantha Bunzli, Peter Choong, Kay M. Crossley, Joanne L. Kemp, Jason A. Wallis, Alison Gibbs, Vincent Lengkong, Allison M. Ezzat, Juanita Low, Zhomart Orman, Nicholas F. Taylor, Anna Wong Shee, Natasha A. Lannin, Ewa M. Roos, Raphael Hau, Angela Cochrane, Mia Pithie, Emma Draffin, David A. Mitchell, Trevor Russell, Danilo de Oliveira Silva

Bibliographic record

VenueOsteoarthritis and Cartilage Open · 2025
Typearticle
Languageen
FieldMedicine
TopicTotal Knee Arthroplasty Outcomes
Canadian institutionsUniversity of British Columbia
FundersNational Health and Medical Research CouncilMedical Research CouncilCanadian Institutes of Health ResearchSt Vincent's Hospital Melbourne
KeywordsOsteoarthritisMedicineCohortProtocol (science)TrajectoryPhysical medicine and rehabilitationPhysical therapyOrthopedic surgerySurgeryAlternative medicineInternal medicinePathology

Abstract

fetched live from OpenAlex

Objective: This parallel cohort-implementation study, termed MonitOring the health Trajectory of patients with kNee osteoarthritis (MOTION), aims to understand treatment pathways and outcomes for people with knee osteoarthritis referred to Australian public hospitals for orthopaedic assessment (Part A cohort study), and how improving access to first-line care might improve outcomes (Part B implementation study). Methods and analysis: We will recruit approximately 400 adults with knee osteoarthritis referred for orthopaedic opinion to one of four public hospitals in Victoria, Australia. A subgroup enrolled in the study (n ​= ​109) will receive improved access to community-based first-line care. Outcomes will be evaluated at baseline, 4-, 8-, 12- (primary end point), 24- and 60-months. The primary outcome will divide the cohort into 1's (willing to undergo, waitlisting for, or undergone, TKR surgery) or 0's (not willing to undergo, not undergone, and not waitlisted for, TKR surgery). Secondary outcomes include pain, knee- and health-related quality of life, physical activity participation and health care utilisation. Surgical and health trajectories will be reported descriptively, with factors associated with outcomes explored. The effectiveness of improving access to first-line care will be determined through propensity score methods. The cost-effectiveness of improving access to first-line care will be also be determined, and semi-structured interviews (1:1 and focus groups) involving participants, health professionals, administrators, and research team will inform a comprehensive process evaluation. Ethics and dissemination: Approved by St Vincent's Hospital Melbourne Human Research Ethics Committee (HREC 251/21). Findings will be disseminated to stakeholders including via conferences, peer-reviewed journals, and social and mainstream media.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.395
Threshold uncertainty score0.524

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0010.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.029
GPT teacher head0.353
Teacher spread0.324 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations2
Published2025
Admission routes2
Has abstractyes

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