Bombyx mori Nucleopolyhedrovirus PE38 Interacts with eIF4E to Benefit Viral Replication in Silkworm, Bombyx mori
Bibliographic record
Abstract
Abstract The silkworm (Bombyx mori) is an economically important insect and a model species of Lepidoptera insects. Bombyx mori nucleopolyhedrovirus (BmNPV), a member of the baculovirus, caused serious damages to the sericulture industry every year. The complex interactions between baculoviruses and their hosts determine the ultimate fate of viral infections. Although it has been reported that Autographa californica multicapsid nucleopolyhedrovirus (AcMNPV) infection induced shutoff of host protein translation, the mechanism remains unclear. In this study, we found the immediately early protein, PE38 of BmNPV, could interact with the eukaryotic translation initiation factor 4E (eIF4E) in the eIF4F complex which initials eukaryotic translation. It was also found that the knockdown of BmeIF4E and the treatment with rapamycin led to an increase in the replication of BmNPV. Taken together, we confirmed that BmNPV manipulates the host translation machinery by expressing PE38 to block the translation initiation complex. Our results may provide valuable information for the potential drug discovery against viral pathogens of insects.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".