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Record W4410267781

Consensus Recommendations for Hyperpolarized [1-<sup>13</sup>C]pyruvate MRI Multi-center Human Studies.

2025· preprint· en· W4410267781 on OpenAlexaff
Shonit Punwani, Peder E.Z. Larson, Christoffer Laustsen, Jan VanderMeulen, Jan Henrik Ardenkjær‐Larsen, Adam Autry, James A. Bankson, Jenna Bernard, Robert Bok, Lotte Bonde Bertelsen, Jenny Che, Albert P. Chen, Rafat Chowdhury, Arnaud Comment, Charles H. Cunningham, Duy Dang, Ferdia A. Gallagher, Adam Gaunt, Jeremy W. Gordon, Ashley Grimmer, James T. Grist, Esben Søvsø Szocska Hansen, Mathilde H. Lerche, Richard L. Hesketh, Jan-Bernd Hoevener, C. Hsieh, Kayvan R. Keshari, Sebastian Kozerke, Titus Lanz, Dirk Mayer, Mary A. McLean, Jae Mo Park, Jim Slater, Damian J. Tyler, Jean‐Luc Vanderheyden, Xu Duan, Daniel B. Vigneron

Bibliographic record

VenuePubMed · 2025
Typepreprint
Languageen
FieldChemistry
TopicAdvanced NMR Techniques and Applications
Canadian institutionsUniversity of TorontoSunnybrook Health Science Centre
Fundersnot available
KeywordsCenter (category theory)Nuclear magnetic resonanceMedicineComputer sciencePhysicsChemistry
DOInot available

Abstract

fetched live from OpenAlex

C-Pyruvate Preparation', 'MRI System Setup, Calibration, and Phantoms', 'Acquisition and Reconstruction', and 'Data Analysis and Quantification'. Consensus was present across categories, examples include that: (i) different HP pyruvate preparation methods could be used in human studies, but that the same release criteria have to be followed; (ii) site qualification and quality assurance must be performed with phantoms and that the same field strength must be used, but that the rest of the system setup and calibration methods could be determined by individual sites;(iii) the same pulse sequence and reconstruction methods were preferable, but the exact choice should be governed by the anatomical target; (iv) normalized metabolite area-under-curve (AUC) values and metabolite AUC were the preferred metabolism metrics. The work confirmed areas of consensus for multi-center study conduct and identified where further research is required to ascertain best practice.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.112
metaresearch head score (Gemma)0.132
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: Not applicable
GenreCandidate signal: Methods · Consensus signal: Methods
Teacher disagreement score0.112
Threshold uncertainty score0.594

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.1120.132
Meta-epidemiology (narrow)0.0020.003
Meta-epidemiology (broad)0.0030.007
Bibliometrics0.0080.007
Science and technology studies0.0030.004
Scholarly communication0.0060.004
Open science0.0200.006
Research integrity0.0180.014
Insufficient payload (model declined to judge)0.0140.019

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.106
GPT teacher head0.366
Teacher spread0.260 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designNot applicable
Domainnot available
GenreMethods

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2025
Admission routes1
Has abstractyes

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Same venuePubMedSame topicAdvanced NMR Techniques and ApplicationsFrench-language works237,207