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Record W4410313757 · doi:10.1093/infdis/jiaf234

<i>Streptococcus pyogenes</i> Surveillance Through Surface Swab Samples to Track the Emergence of Streptococcal Toxic Shock Syndrome in Rural Japan

2025· article· en· W4410313757 on OpenAlexaff
Dhammika Leshan Wannigama, Mohan Amarasiri, Phatthranit Phattharapornjaroen, Cameron Hurst, Charin Modchang, Yu Suzuki, Kyoji Moriya, Kazuhiko Miyanaga, Longzhu Cui, Angkana T. Huang, Daisuke Akaneya, Jun Igarashi, Mark J. Suto, Daisuke Ishizawa, Wakana Imamiya, A. Igarashi, Yoshitaka Shimotai, Andrew C. Singer, Naveen Kumar Devanga Ragupathi, Takashi Furukawa, Kazunari Sei, Yangzhong Wang, Talerngsak Kanjanabuch, Paul G. Higgins, Nobuhito Nemoto, Aisha Khatib, Anthony Kicic, Sam Trowsdale, Parichart Hongsing, Daisuke Sano, Kenji Shibuya, Shuichi Abe, Hiroshi Hamamoto

Bibliographic record

VenueThe Journal of Infectious Diseases · 2025
Typearticle
Languageen
FieldMedicine
TopicStreptococcal Infections and Treatments
Canadian institutionsUniversity of Toronto
FundersJapan Society for the Promotion of ScienceCentre of Excellence in Mathematics, Mahidol UniversityMinistry of Higher Education, Science, Research and Innovation, ThailandMinistry of Health, Labour and WelfareThailand Center of Excellence in Physics
KeywordsStreptococcus pyogenesToxic shock syndromeVirulenceMicrobiologyShock (circulatory)STREPTOCOCCAL INFECTIONSStreptococcusStreptococcus agalactiaeBiologyMedicineBacteriaGeneticsInternal medicineStaphylococcus aureusGene

Abstract

fetched live from OpenAlex

Japan recently experienced a record surge in streptococcal toxic shock syndrome. Our environmental surveillance study reveals that Streptococcus pyogenes persists seasonally, peaking in autumn and winter in rural Japan. The dominant emm1 M1UK sublineage and csrS mutations heighten virulence, highlighting the urgent need for targeted surveillance and interventions.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.001
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.024
Threshold uncertainty score0.047

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0010.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0010.001
Science and technology studies0.0000.000
Scholarly communication0.0010.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.014
GPT teacher head0.297
Teacher spread0.283 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations3
Published2025
Admission routes1
Has abstractyes

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