Advances in the Structure–Activity Relationship of Electrocatalytic C–N Coupling: From Nanocatalysis to Single Metal Site Catalysis
Bibliographic record
Abstract
C-N coupling is crucial for constructing amides and amines and involves various fields, including medicine, chemical industries, agriculture, and energy. With the rapid development of electrocatalytic C-N coupling and the continuous improvement of catalytic performance, this field has aroused extensive research interest. A comprehensive review is urgently needed to summarize the structure-activity relationship, key challenges, and future development directions. This review provides a concise overview of the recent advancements from nanocatalysis to single metal site catalysis for electrocatalytic C-N coupling reactions. We summarize the C-N coupling mechanisms using different nitrogen sources and further analyze the influences of various active metal centers and different coordination environments on the C-N coupling performance, thereby elucidating the structure-activity relationship. Moreover, we discuss the dynamic structural evolution of active metal sites during the reaction. Finally, we present current challenges and perspectives in this field. This review aims to provide valuable insights into the development of advanced nano/single metal site catalysts for electrocatalytic C-N coupling reactions along with a deeper understanding of catalytic mechanisms.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.002 | 0.001 |
| Bibliometrics | 0.000 | 0.002 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".