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Record W4410379821 · doi:10.1111/cts.70247

Physiologically Based and Population Pharmacokinetic Modeling of Midazolam in Children With Obesity Using Real‐World Data

2025· article· en· W4410379821 on OpenAlexaff
Sean McCann, Victória Etges Helfer, Stephen J. Balevic, William J. Muller, John van den Anker, Amira Al‐Uzri, Marisa Meyer, Sarah G. Anderson, Sitora Turdalieva, Andrea N. Edginton, Daniel González

Bibliographic record

VenueClinical and Translational Science · 2025
Typearticle
Languageen
FieldMedicine
TopicAnesthesia and Sedative Agents
Canadian institutionsUniversity of Waterloo
FundersDuke Clinical Research InstituteNational Institute of Child Health and Human DevelopmentNational Institutes of HealthEunice Kennedy Shriver National Institute of Child Health and Human DevelopmentUniversity of North Carolina at Chapel HillChildhood Arthritis and Rheumatology Research AlliancePenn State College of MedicineWichita Medical Research and Education FoundationUniversity of South CarolinaPennsylvania State UniversityGlaxoSmithKlineIndiana University HealthUniversity of LouisvilleNational Center for Advancing Translational SciencesChildren's Hospital ColoradoYale UniversityCincinnati Children's Hospital Medical CenterChildren's National HospitalUniversity of PennsylvaniaChildren's Hospital of Philadelphia
KeywordsMidazolamMedicinePharmacokineticsObesityPopulationDosingOverweightCovariateNONMEMPharmacologyInternal medicineEnvironmental healthMachine learningComputer science

Abstract

fetched live from OpenAlex

OpenAlex records an abstract for this work, but it could not be fetched just now.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.412
Threshold uncertainty score0.161

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.143
GPT teacher head0.430
Teacher spread0.287 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations3
Published2025
Admission routes1
Has abstractyes

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