Whole Abdominal Radiotherapy Is Tolerable and Effective in Children and Young Adults With Intra‐Abdominal Sarcoma: A Canadian Sarcoma Research and Clinical Collaboration (CanSaRCC) Study
Bibliographic record
Abstract
BACKGROUND: Whole abdominal radiotherapy (WART) is utilized in children, adolescents, and young adults with intra-abdominal sarcoma, but efficacy and toxicity are uncertain. METHODS: Sarcoma patients diagnosed at ≤39 years of age between 1998 and 2023 who received WART were identified from a national registry. Patient and tumor characteristics, treatment, response, and survival outcomes were assessed. RESULTS: Twenty patients with desmoplastic small round cell tumor (DSRCT) (n = 7), rhabdomyosarcoma (RMS) (n = 6), Ewing sarcoma, rhabdoid tumor, endometrial stromal tumor (each n = 1), and sarcoma not-otherwise-specified (NOS) (n = 4) were included. Among 17 patients who received WART as part of upfront therapy, 16 had abdominal metastatic disease (94.1%) (peritoneal deposits n = 9, malignant ascites n = 8 [including two with both peritoneal deposits and malignant ascites] and liver metastases n = 1), while one was initially localized. Median WART dose was 22.5 Gy (range: 10.5-30); median kidney and liver doses were 14.9 Gy (range: 7.7-20.7) and 21.0 Gy (range: 13.1-27.7), respectively. Three patients developed Grade 3 acute toxicity; diarrhea (n = 2) or elevated creatinine (n = 1); two RMS patients developed second malignancies. Two-year overall and progression-free survival estimates were 100% and 80% (95% confidence interval [CI]: 51.6%-100%) in RMS; 62.5% (95% CI: 32%-100%) and 50% (95% CI: 22.5%-100%) in DSRCT. Five-year cumulative incidence of abdominal recurrence was 33.3% (95% CI: 11.4%-57.3%) with WART failure in DSRCT (n = 2) and sarcoma NOS (n = 1). Three patients received WART following relapse; all recurred; two within the WART field. CONCLUSIONS: WART is well tolerated among young sarcoma patients and provides meaningful local disease control when utilized in front-line adjuvant therapy.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".