Antifungal naphthalenes and related polyketides from the cranberry (Vaccinium macrocarpon) endophyte Protoventuria sp.
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
Ericaceous plants, including high-value fruit crops, harbor phylogenetically diverse fungal endophytes. A collection of ∼350 fungal endophytes from Canadian fruit-bearing plants was generated to investigate the taxonomic and secondary metabolite diversity of these poorly studied fungi. A putatively novel species of Protoventuria was isolated as an endophyte from a cranberry ( Vaccinium macrocarpon ) leaf in Central Ontario promoting an investigation of its secondary metabolites. From this fungus, two new naphthalenes, protoventurenes A and B ( 1 – 2 ), were characterized by LC-HRMS and NMR spectroscopy. Two additional structurally similar metabolites were also identified, the naphtalenone fragranone ( 3 ), previously reported from a shrub in Thailand, and the phenalenone derivative lamellicolic anhydride ( 4 ) originally from Verticillium lamellicola . Metabolites 1 – 4 inhibited the growth of the plant pathogen Botrytis cinerea with a 100-µg dose, and protoventurene B ( 2 ) inhibited Colletotrichum gloeosporioides at the same concentration. The investigation of ericaceous endophytes continues to reveal ecologically unique fungi and their new secondary metabolites.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it