Identifying opioid agonist treatment prescriber networks from health administrative data: A validation study
Bibliographic record
Abstract
BACKGROUND: Given the growth of collaborative care strategies for people with opioid use disorder and the changing composition of the illicit drug supply, there is a need to identify and analyze clinic-level outcomes for centers prescribing opioid agonist treatment (OAT). We aimed to determine and validate whether prescriber networks, constructed with administrative data, can successfully identify distinct clinical practice facilities in Ontario, Canada. METHODS: We executed a retrospective population-based cohort study using OAT prescription records from the Canadian Addiction Treatment Centres in Ontario, Canada between 01/01/2013 and 12/31/2020. Social network analysis was utilized to create networks with connections between physicians based on their shared OAT clients. We defined connections two different ways, by including the number of clients shared or a relative threshold on the percentage of shared OAT clients per physician. Clinics were identified using modularity maximization, with sensitivity analyses applying Louvain, Walktrap, and Label Propagation algorithms. Concordance between network-identified facilities and the (gold standard) de-identified facility-level IDs was assessed using overall, positive and negative agreement, sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV). RESULTS: From 144 physicians at 105 clinics with 32,842 OAT clients, we assessed 250 different versions of the created networks. The three different detection algorithms had wide variation in concordance, with ranges on sensitivity from 0.02 to 0.88 and PPV from 0.06 to 0.97. The optimal result, derived from the modularity maximization method, achieved high specificity (0.98, 95% CI: 0.98, 0.98) and NPV (0.98, 95% CI: 0.97, 0.98) and moderate PPV (0.54, 95% CI: 0.52, 0.57) and sensitivity (0.45, 95% CI: 0.43, 0.47). This scenario had an overall agreement of 0.96, negative agreement of 0.98, and positive agreement of 0.49. CONCLUSIONS: Social network analysis can be used to identify clinics prescribing OAT in the absence of clinic-level identifiers, thus facilitating construction and comparison of clinic-level caseloads and treatment outcomes.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.018 | 0.066 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.001 |
| Bibliometrics | 0.003 | 0.002 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.002 | 0.002 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".