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Record W4410450843 · doi:10.3389/fphar.2025.1513318

Global research trends and hotspots in aspirin studies (2014–2024): a bibliometric perspective

2025· review· en· W4410450843 on OpenAlexaboutno aff
Ning Sun, Bochao Jia, Rui Wei, Taiwei Lou, Zirong Li, Xiaowei Nie, Wenxiao Yu, Qiuyan Li

Bibliographic record

VenueFrontiers in Pharmacology · 2025
Typereview
Languageen
FieldMedicine
TopicInflammatory mediators and NSAID effects
Canadian institutionsnot available
FundersNatural Science Foundation of Beijing Municipality
KeywordsAspirinChinaBibliometricsWeb of scienceMedicineLibrary scienceGeographyComputer sciencePathologyInternal medicineMeta-analysis

Abstract

fetched live from OpenAlex

Background: Aspirin, as one of the most important drugs in medical history, has been continuously explored for over 3,000 years. This study employs bibliometric analysis to examine the research hotspots and trends on aspirin over the past decade. Methods and results: This study retrieved articles and reviews on aspirin from the Web of Science database, covering the period from 2014 to 2024. R software and CiteSpace were employed for visual analysis, revealing trends in publication volume, collaborations, core journals, and keywords distributions. In the past decade, a total of 19,504 papers authored by 88,600 researchers were published, citing 460,704 references. The U.S., China, and Italy lead in publications, with Canada and Australia showing strong collaboration. The authors with the highest contributions include BHATT DL, STEG PG, and WANG YJ. Research hotspots and trends include the following three points: the development of expert recommendations for the use of aspirin in primary cardiovascular prevention into personalized and shared decision-making between doctors and patients; the ongoing need for more evidence regarding the effects of aspirin on different tumors; and the sustained focus on aspirin-related respiratory diseases in future research. Conclusion: Aspirin, a classic drug, continues to have a substantial number of publications, underscoring its lasting impact. The United States, China, and Italy play a leading role in this field. However, there is still a long way to go, and research that is more targeted and beneficial for different refined populations may be a future trend.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Direct model labels (unvalidated)

Per-model category and study-design labels from the labeling rounds. They are machine output, unvalidated, and the disagreement between models ships as data. No study design here is MEDLINE-validated yet.

Model armCategoriesStudy designConfidence
gemmaBibliometrics
Domain: not available · Genre: Review
About the Canadian research system: no · About a Canadian topic: no
Observationallow
gptBibliometrics
Domain: not available · Genre: Review
About the Canadian research system: no · About a Canadian topic: no
Other designhigh
models splitAgreement compares identical category sets and study designs across arms.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.003
metaresearch head score (Gemma)0.001
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMeta-epidemiology (narrow), Bibliometrics
Consensus categoriesBibliometrics
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.675
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0030.001
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0030.000
Bibliometrics0.0920.083
Science and technology studies0.0000.001
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0010.002
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.092
GPT teacher head0.515
Teacher spread0.423 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Labeled directly by 2 models reading the full record.

Bibliometrics

The models disagree on parts of this classification; every voice is preserved in the section at the end of the page.

Study designObservational · Other design
Domainnot available
GenreReview

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2025
Admission routes1
Has abstractyes

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