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Record W4410456228 · doi:10.1126/science.adk5081

From North Asia to South America: Tracing the longest human migration through genomic sequencing

2025· article· en· W4410456228 on OpenAlexaboutno aff
Elena S. Gusareva, Amit Gourav Ghosh, V. N. Kharkov, Seik‐Soon Khor, А. А. Зарубин, Nikita Moshkov, Namrata Kalsi, Aakrosh Ratan, Cassie E. Heinle, Niall P. Cooke, Cláudio M. Bravi, M. V. Smolnikova, Sergey Tereshchenko, Э. В. Каспаров, I. Yu. Khitrinskaya, Andrey Marusin, Magomed O. Razhabov, М. В. Голубенко, M. G. Swarovskaya, Н. А. Колесников, Е. Р. Еремина, Aitalina Sukhomyasova, О. В. Штыгашева, Deepa Panicker, Poh Nee Ang, Choou Fook Lee, Yanqing Koh, See Ting Leong, Changsook Park, Sachin R. Lohar, Zhei Hwee Yap, Soo Guek Ng, Justine Dacanay, Daniela I. Drautz‐Moses, Nurul Adilah Binte Ramli, Katsushi Tokunaga, Ian McGonigle, Inaho Danjoh, Andrés Moreno‐Estrada, Atsushi Tajima, Hideyuki Tanabe, Yukio Nakamura, Shigeki Nakagome, Tatiana V. Tatarinova, Vadim Stepanov, Stephan C. Schuster, Hie Lim Kim

Bibliographic record

VenueScience · 2025
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicForensic and Genetic Research
Canadian institutionsnot available
Fundersnot available
KeywordsTracingGenomic sequencingGeographyOut of africaEvolutionary biologyComputational biologyBiologyGeneticsGenomeComputer scienceGene

Abstract

fetched live from OpenAlex

Genome sequencing of 1537 individuals from 139 ethnic groups reveals the genetic characteristics of understudied populations in North Asia and South America. Our analysis demonstrates that West Siberian ancestry, represented by the Kets and Nenets, contributed to the genetic ancestry of most Siberian populations. West Beringians, including the Koryaks, Inuit, and Luoravetlans, exhibit genetic adaptation to Arctic climate, including medically relevant variants. In South America, early migrants split into four groups-Amazonians, Andeans, Chaco Amerindians, and Patagonians-~13,900 years ago. Their longest migration led to population decline, whereas settlement in South America's diverse environments caused instant spatial isolation, reducing genetic and immunogenic diversity. These findings highlight how population history and environmental pressures shaped the genetic architecture of human populations across North Asia and South America.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.299
Threshold uncertainty score0.286

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.021
GPT teacher head0.311
Teacher spread0.290 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations15
Published2025
Admission routes1
Has abstractyes

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