1216 Autonomic Dysregulation During Sleep in Premenstrual Dysphoric Disorder
Bibliographic record
Abstract
Abstract Introduction Premenstrual Dysphoric Disorder (PMDD) is a menstrual cycle-related mood disorder, frequently associated with insomnia during the luteal phase (LP). Mood disorders and sleep disturbances are independently associated with altered autonomic nervous system (ANS) function. Research suggests that the menstrual cycle modulates ANS during wakefulness, with decreased parasympathetic activity from the follicular to LP. We hypothesize disturbed ANS regulation during sleep in PMDD during the symptomatic LP. This study aimed to investigate whether menstrual cycle–related variation in ANS activity is accentuated in women with PMDD compared to controls, and how such differences might relate to anxiety and sleep quality. Methods Seven women (32.0 ± 5.7 years) with PMDD-related LP insomnia and five healthy controls (30.4 ± 8.2 years) underwent polysomnography every third night across one menstrual cycle (n=96 nights). Heart rate variability (HRV) measures, including high frequency (HF), low frequency (LF), LF/HF ratio, and rMSSD, were extracted from non-rapid eye movement (NREM) sleep. Menstrual phase and group effects were evaluated using mixed-model ANOVA. Morning questionnaires assessed anxiety (visual analogue scale) and sleep quality (7-point Likert scale), which were correlated with HRV parameters. Results Compared to controls, PMDD participants showed significantly reduced HF (F1,24=7.4 p= 0.008) and rMSSD (F1,24=16.4, p < 0.001), reflecting lower vagal tone, and elevated LF/HF ratios (F1,24=35.0, p < 0.001), an index of HRV reflecting sympathetic and parasympathetic nerve activity. No main effects of the menstrual phase or interaction effects were found. Anxiety was associated positively with LF/HF ratio (r=0.32, p=0.02) and negatively with rMSSD (r=-0.42, p=0.003). No significant association was found between HRV parameters and reported sleep quality. Conclusion These results suggest a stable, trait-like autonomic vulnerability in PMDD, independent of the menstrual phase, characterized by diminished parasympathetic activity. The lack of a menstrual phase effect may reflect differences from previous studies, which primarily assessed ANS during wakefulness, or could be due to our limited sample size. Furthermore, our findings suggest a potential relationship between autonomic dysregulation during sleep and elevated anxiety in PMDD, independent of changes in sleep quality. Support (if any) This study was supported the Canadian Institutes of Health Research (CIHR, grant MOP-38064).
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".