A RARE PRESENTATION OF AN OVERLAP CONNECTIVITY AS PURPURA FULMINANS: A CASE REPORT
Bibliographic record
Abstract
PV286 / #392 Case Report Poster Topic: AS07 - Cutaneous Lupus Introduction Autoimmunity, by its complexity, involves various lesional mechanisms both structurally and functionally. Its association with hemostasis disorders amplifies this damage and darkens the prognosis. Case Presentation With Investigation We report a case of purpura fulminans revealing an overlapping syndrome associating dermatomyositis, systemic lupus with secondary antiphospholipid syndrome. Observation: A 56-year-old diabetic woman, hypertensive, followed for Hashimoto’s thyroiditis is admitted for the management of a systemic picture made of: an inflammatory myopathy retained on the clinic, morphology and histopathology; a glomerular syndrome with on the kidney membranousproliferative nephritis. The histopathological study of the skin biopsy is in favor of immune pauci leukocytoclastic vasculitis with multiple microthrombi.All of this is evolving in a febrile context. After excluding infectious causes, the etiological investigation is in favor of an overlapping syndrome: systemic lupus, dermatomyositis with secondary APS. The patient benefited from immunosuppressive treatment combined with plasmapheresis sessions and antithrombotic treatment with a favorable outcome. Conclusion: Purpura fulminans is a manifestation that is not limited to an infectious cause. He may be the witness of a dysimmune and/or hematological disorder. Literature Review [1.] Lyon P. BMJ Case Rep 2011;2011:bcr0320113996. [2.] Harikrishna J. Indian J Med Res 2015;141(1):130-1. Discussion Purpura fulminans is a manifestation that is not limited to an infectious cause. He may be the witness of a dysimmune and/or hematological disorder.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.003 |
| Meta-epidemiology (narrow) | 0.003 | 0.002 |
| Meta-epidemiology (broad) | 0.002 | 0.001 |
| Bibliometrics | 0.005 | 0.004 |
| Science and technology studies | 0.003 | 0.002 |
| Scholarly communication | 0.003 | 0.004 |
| Open science | 0.002 | 0.003 |
| Research integrity | 0.008 | 0.004 |
| Insufficient payload (model declined to judge) | 0.005 | 0.002 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".