INITIAL CLINICAL PRESENTATION OF SYSTEMIC LUPUS ERYTHEMATOSUS IN THE GUATEMALAN POPULATION: ISLA COHORT
Bibliographic record
Abstract
PV224 / #403 Poster Topic: AS23 - SLE-Diagnosis, Manifestations, & Outcomes Background/Purpose Systemic lupus erythematosus (SLE) is a complex autoimmune disease that affects multiple organ systems and exhibits a diverse range of clinical manifestations, predominantly in young women. The characteristics of the initial presentation may vary significantly based on the demographic and geographic context of the affected population. This study seeks to elucidate SLE’s clinical behavior in patients from the Guatemalan lupus cohort. Methods The records of 268 patients diagnosed with SLE and followed up from December 2008 to June 2024 were analyzed in a retrospective cross-sectional study. These patients constituted a cohort from a single rheumatology center in Guatemala, specifically the Lupus cohort of the Guatemalan Social Security Institute in the Autonomous Unit (ISLA). The clinical manifestations observed during diagnosis were assessed utilizing the ACR/EULAR 2019 and SLICC 2012 classification criteria. The data characterization was systematically organized by gender. Results Our findings indicate that 91.42% of patients diagnosed with SLE were women, with a mean age of 30.56 years for females and 26.6 years for males, and predominantly came from the metropolitan area. Notably, 93.5% of females and 87% of males fulfilled the ACR/EULAR 2019 classification criteria, while all patients fulfilled the SLICC criteria (Table 1). The most common clinical manifestation was renal involvement, present in 46.9% of females and 69.9 % of males, primarily types III and IV nephropathy. Arthritis affected 55.5% of females and 39.1% of males. Regarding immunological conditions, ANA positivity was observed in 93.5% of females and 87% of males, while anti-dsDNA positivity was noted in 80.4% and 60.9%, respectively. Males predominantly exhibited renal involvement and a higher frequency of aPL with a higher frequency of thrombotic APS, whereas females exhibited mucocutaneous, renal, and neurological manifestations (Table 2). Table 1. Table 2. Conclusions Our study’s findings emphasize the importance of recognizing the main clinical manifestations of SLE in our population, particularly the renal, joint, and mucocutaneous involvement, and their association with immunological phenomena and the presence of antiphospholipid antibodies in men. This understanding should motivate healthcare professionals, as it equips them with the knowledge to suspect SLE when these clinical characteristics are present, thereby improving patient care and outcomes.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.002 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.000 | 0.001 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".