CARDIAC LUPUS: A DISEASE NOT TO BE NEGLECTED.
Bibliographic record
Abstract
PV205 / #486 Poster Topic: AS23 - SLE-Diagnosis, Manifestations, & Outcomes Background/Purpose Systemic lupus erythematosus (SLE) is an autoimmune disease affecting several organs, including the heart. Cardiac involvement is variable, affecting all tunics. Echocardiography enables early diagnosis of cardiac manifestations of SLE. The aim of this study was to analyze the various cardiac abnormalities in patients with lupus. Methods This was a retrospective, descriptive study carried out in the internal medicine department of IBN ROCHD university hospital in Casablanca, covering the records of patients hospitalized between 2010 and 2023 for SLE (retained on ACR and SLICC criteria). We studied cases with cardiac manifestations. Results In a series of 360 cases of SLE, cardiac manifestations were found in 49 patients (13.61%), with an average age of 32 years and extremes between 18 and 63 years; 47 were women and 2 men, indicating a clear female predominance. Cardiac involvement revealed the disease in 34 cases. Lupus pericarditis was the most frequent cardiac manifestation (71.42%), followed by valve damage (10.2%) of mitral insufficiency (5 cases), Libmann-Sacks endocarditis (3 cases), PAH and myocarditis, There were 3 cases of tamponade. Clinically, the most frequent symptoms were chest pain in 20 cases (41%) and dyspnea in 13 cases (28.2%). Chest X-rays revealed cardiomegaly in 13 patients. ECG abnormalities were found in 20 patients, including rhythm and/or conduction disorders and microvoltage. Cardiac ultrasound confirmed the diagnosis of pericarditis and valvulopathy, and detected pulmonary hypertension (PH). Myocardial damage required MRI confirmation, showing focal subepicardial contrast and endomyocardial fibrosis. Treatment was based on corticosteroid therapy in 100% of cases, with cyclophosphamide indicated in 20 patients, followed by azathioprine in 13 and mycophenolate mofetil in the others, in addition to specific cardiac treatments in all patients. Progression was favorable in 18 patients (36.73), less so in cases of heart failure or severe rhythm disorders. Conclusions Cardiac involvement in SLE is frequent and serious, and should be systematically investigated even in the absence of any clinical symptoms. Cardiac echocardiography remains an excellent noninvasive tool for detecting severe cardiac involvement in SLE.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.000 | 0.001 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.007 | 0.002 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".