WORK OUTCOMES AND PREDICTORS OF EARLY WORK CESSATION IN INDIVIDUALS LIVING WITH SYSTEMIC LUPUS ERYTHEMATOSUS: INSIGHTS FROM THE CANADIAN CANIOS COHORT
Bibliographic record
Abstract
PV174 / #623 Poster Topic: AS19 - Patient-Reported Outcome Measures Background/Purpose Early work cessation is a significant contributor to the personal and societal costs associated with systemic lupus erythematosus (SLE). We sought to describe work status in people with diagnosed SLE and to identify factors associated with early work cessation. Methods We used data from the multicenter Canadian Network for Improved Outcomes in Systemic lupus erythematosus cohort (CaNIOS). Lupus symptoms were assessed using the self-reported SLE activity questionnaire (SLAQ). Health-related quality of life which reflects health status was assessed using the Short-Form 36 physical and mental component scores (PCS and MCS respectively). Work status [working at least 10 hours per week, retired, full-time student, disabled, full-time homemaker] and hours worked/week (categorized as 1-15, 16-30, >30 hrs) were reported annually. We evaluated work status at baseline and during follow-up in participants of working age (defined as <66, the average retirement age in Canada). We defined incident SLE as having the baseline study visit within 12 months of diagnosis. Binary logistic regression analysis was used to identify variables associated with baseline work status. Models included gender, duration of lupus, achievement of high school education, SLAC, PCS and MCS. Results Work status was available for 2194 working age participants (90.6% women, mean age 43 (12.7) years, 1910/2170 (88%) completed high school, 693/1245(56%) had insurance for disability, 1040/1350 (77%) for prescription drugs, and 811/1267(64% for physiotherapy). At the baseline visit, for prevalent cases, 1158/(52.8%) were working, 214(9.8%) were retired, 225 (10.3%) were full-time homemakers, 145(6.6%) were full-time students and 363 (16.5%) were disabled. Of working age participants 269 had incident SLE. For the 269 incident SLE participants of working at the baseline visit 157 (58.4%) were working, 19 (7.1%) were retired, 27(10.1%) were full-time homemakers, 21 (7.8%) were full-time students and 33 (12.3%) were disabled. Work status was stable during follow-up as were overall hours worked (Figure). In the subset of participants with available data (N=407), high school completers (OR 3.0 (1.61,5.65), higher (better) PCS (1.07 (1.04, 1.09) and MCS (1.03 (1.01, 1.05), and higher SLAQ 1.045(1.01, 1.08) were associated with working at baseline; gender (OR 1.5(0.72,3.32) and disease duration OR 0.99(0.97, 1.01) were not. Figure: Employment status overtime A . Prevalent SLE, B . Incident SLE, C . Hours worked prevalent SLE, D . Hours worked incident SLE Conclusions Patients with SLE are employed at lower rates than the general Canadian population. Employment appears to be influenced by both demographic factors such as education and both physical and mental health status. Strategies to improve employment rates for people with SLE are needed.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".