SOCIODEMOGRAPHIC PROFILE AND INITIAL CLINICAL PRESENTATIONS IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS AMONG BANGLADESHI POPULATION
Bibliographic record
Abstract
PV200 / #278 Poster Topic: AS23 - SLE-Diagnosis, Manifestations, & Outcomes Background/Purpose Systemic lupus erythematosus (SLE) is an autoimmune multisystem disease characterized by a diverse range of organ involvement and clinical manifestations. The presentation of SLE has significant geographical variation, with the disease being more prevalent among Asian, Hispanic, and Afro-American populations. The incidence and prevalence of SLE vary widely across different regions. Alongside variations in epidemiological subgroups such as race/ethnicity, gender, and age of onset; other sociodemographic factors including socioeconomic status, education level, and access to medical care, can influence disease activity and outcomes. This study aimed to identify the sociodemographic profile and initial clinical presentation of SLE patients among Bangladeshi population. Methods This cross-sectional observational study was conducted at the Green Life Center for Rheumatic Care and Research and the Green Life Medical College Hospital from July 2022 to June 2024. Patients diagnosed with SLE who met the classification criteria of either 1997 American College of Rheumatology (ACR) or 2012 Systemic Lupus International Collaborating Clinics (SLICC), or 2019 EULAR/ACR were included. Patients with overlap, MCTD or unwilling to participate were excluded. A total of 252 consecutive SLE patients were enrolled. Investigators conducted face-to-face interviews and reviewed medical records to gather information on the sociodemographic profile and initial clinical presentations within the first 3 months of disease onset. Data were collected using a preformed data sheet and analyzed using SPSS version 25, calculating percentages and frequencies as appropriate. Results Among the 252 patients, the majority were female (92%), resulting in a female-to-male ratio of 11.6:1. The mean age was 29.5 ± 10.6 years, with men being younger on average than women (27.5 years vs. 29.6 years). Approximately two-thirds of the participants resided in urban areas, with 62% being married, 48% identified as homemakers, and 35% as students. Over 90% of the participants had at least a primary education, and 26% were graduates. Most participants (58%) belonged to the low to lower-middle socioeconomic class, with a monthly income ranging from 10,000 to 30000 BDT. None were smoker. The most common initial clinical presentations were alopecia (85%), followed by fatigue (82.5%) and arthralgia/arthritis (80%). Additionally, 68% reported a history of fever, 64% presented with oral ulcers, 60% had various rashes, and 47% had photosensitivity. Headaches were reported by 60% of the patients. The most common initial major organ involvement was renal (41% with proteinuria and 11% with elevated serum creatinine). Anemia was observed in 70% of patients, with 24% having autoimmune hemolytic anemia, 22% had thrombocytopenia, and 14% with leukopenia. Other notable features included a history of Raynaud’s phenomenon (35%), pleural effusion (15%), convulsions (12%), psychosis (8%), pericardial effusion (4%), and other manifestations (18%). Around 60% of patients presented with more than 2 features initially. Over 50% of patients experiencing a delay of more than 6 months, and 23% requiring more than 2 years from initial presentations to final diagnosis. Conclusions The sociodemographic profile of this cohort showed that lupus affects young females, most of them are married or students and belonged to low socioeconomic backgrounds. The initial presentations were largely nonspecific. High index of suspicion is required for early diagnosis. Alopecia, fatigue, and arthralgia/arthritis were identified as the most frequent initial symptoms. Other common presenting features included fever, headaches, and anemia. Some patients may present with major organ involvement, especially renal or neuropsychiatric. Recognition of these features in young females should prompt further evaluation for SLE.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.000 | 0.001 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".