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Record W4410519647 · doi:10.1101/2025.05.14.654080

Repeated Subconcussive Head Impacts Compromise White Matter Integrity and Bimanual Coordination in Collegiate Football Players

2025· preprint· en· W4410519647 on OpenAlexaff
Sebastian D’Amario, Blaire T. Magee, M Wilson, Gabriel Ramirez Garcia, Nicole S. Coverdale, Douglas J. Cook

Bibliographic record

VenuebioRxiv (Cold Spring Harbor Laboratory) · 2025
Typepreprint
Languageen
FieldMedicine
TopicAdvanced Neuroimaging Techniques and Applications
Canadian institutionsQueen's University
Fundersnot available
KeywordsHead (geology)CompromiseFootballFootball playersCollege footballAeronauticsEngineeringHistoryPolitical science

Abstract

fetched live from OpenAlex

Abstract Objectives To determine whether repetitive subconcussive impacts in collegiate football are associated with altered white matter microstructure, motor control deficits, and changes in concussion symptoms across a single season. Design Cohort study with non-contact controls and stratification of contact athletes by head-impact exposure. Method Twenty-two male varsity football players and 27 non-contact controls underwent pre-season diffusion tensor imaging. Tract-specific fractional anisotropy (FA) and mean diffusivity (MD) were derived from commissural and association tracts using probabilistic tractography. Helmet-mounted accelerometers quantified head-impact frequency and gForce over the season, classifying athletes into high (HE) and low-exposure (LE) groups. Football players completed the Kinarm Ball-on-Bar bimanual coordination task and SCAT3 symptom checklist pre- and post-season. Results At pre-season, contact athletes showed altered white matter microstructure versus controls, with higher FA and predominantly lower MD across most tracts. Over the season, HE athletes sustained more total impacts and gForce than LE athletes and showed declining bimanual coordination on the Ball-on-Bar motor task. SCAT3 symptom and severity scores were low and showed no differences in change. Conclusions Repetitive subconcussive exposure in collegiate football is associated with persisting white matter differences and subtle bimanual motor coordination deficits that are not detected by routine symptom-based tools, supporting the use of advanced neuroimaging and robotic motor assessment to monitor athlete brain health.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.001
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.011
Threshold uncertainty score0.023

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0010.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0020.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.034
GPT teacher head0.308
Teacher spread0.274 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2025
Admission routes1
Has abstractyes

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