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Choosing Wisely Canada recommendations for clinical biochemistry: test ordering for sustainable and high-quality patient care

2025· article· en· W4410552587 on OpenAlexafffundabout
Daniel R. Beriault, Yu Chen, Paul S. F. Yip, Ivan M. Blasutig, Vipin Bhayana, Angela C. Rutledge, Michelle Parker, David W. Kinniburgh, Dylan Thomas, Penny D. Colbourne, Loralie J. Langman, Sarah Delaney, Melissa J. Bennett, Curtis Oleschuk, Huang Yun, Karina Rodríguez-Capote, Kristin Hauff, Danijela Konforte, Jay Kalra, Ihssan Bouhtiauy, Mohamed Abou El Hassan, Manal O. Elnenaei, Laurel Thorlacius, Allison A. Venner, Edward Randell, K.-Y. Sohn, Felix Leung, Amy Lou, Saranya Arnoldo

Bibliographic record

VenueClinical Biochemistry · 2025
Typearticle
Languageen
FieldMedicine
TopicCeliac Disease Research and Management
Canadian institutionsTrillium Health CentreMemorial University of NewfoundlandShared HealthManitoba HealthCalgary Laboratory ServicesVitalité Health NetworkSaskatchewan HealthSaskatchewan Health AuthorityAssociated Medical ServicesUniversity of British Columbia, Okanagan CampusUniversité de MonctonUniversity of TorontoUniversity of AlbertaMount Sinai HospitalUniversity of CalgaryChildren's Hospital of Eastern OntarioSunnybrook Health Science CentreQueen's UniversityLondon Health Sciences CentreInterior HealthDalhousie UniversityDr. Everett Chalmers Regional HospitalPublic Health Ontario
FundersCanadian Society of Clinical Chemists
KeywordsMedicineHealth careSustainabilityHarmTest (biology)Patient careIntensive care medicineMedical emergencyNursingPsychology

Abstract

fetched live from OpenAlex

Laboratory Medicine is growing at a rapid rate in both the breadth of unique tests and the total number of tests performed per year. Inappropriate overutilization of laboratory tests can lead to patient harm, excessive environmental waste and increased carbon emissions. A focus on reducing inefficiencies in healthcare is needed to ensure a robust and sustainable healthcare system. To promote laboratory sustainability, the Canadian Society of Clinical Chemists (CSCC) has developed ten recommendations related to medical tests within clinical biochemistry. These recommendations are designed as 'low-hanging fruit' that should be adopted by both hospital and community laboratories. By implementing automated strategies and/or educational approaches to reduce misuse of laboratory resources, clinical laboratories can move toward a more sustainable model that improves patient care. This list of recommendations, created for Choosing Wisely Canada, covers tests for diabetes, celiac disease, monoclonal gammopathies, iron disorders, liver disorders, kidney disorders, substance use disorders, and allergen testing.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.011
metaresearch head score (Gemma)0.081
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: Not applicable
GenreCandidate signal: Methods · Consensus signal: none
Teacher disagreement score0.975
Threshold uncertainty score0.993

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0110.081
Meta-epidemiology (narrow)0.0010.001
Meta-epidemiology (broad)0.0010.001
Bibliometrics0.0030.003
Science and technology studies0.0100.005
Scholarly communication0.0110.004
Open science0.0030.004
Research integrity0.0130.017
Insufficient payload (model declined to judge)0.0280.008

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.049
GPT teacher head0.443
Teacher spread0.394 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designNot applicable
Domainnot available
GenreMethods

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

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Citations3
Published2025
Admission routes3
Has abstractno

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