A novel treatment for emphysema in a porcine model: extracorporeal radiofrequency
Bibliographic record
Abstract
<title>Extract</title> Lung volume reduction surgery (LVRS) remains the only intervention shown to significantly reduce both morbidity and mortality in selected patients with severe emphysema [1, 2]. The excision of emphysematous tissue enhances lung mechanics, subsequently improving outcomes in COPD patients. Nevertheless, the substantial perioperative risks and costs associated with LVRS have limited its clinical utilization [1–3]. Radiofrequency (RF) treatment is a novel non-invasive treatment for emphysema tested in pre-clinical studies. Previous studies indicate that extracorporeal application of RF selectively heats emphysematous tissue — characterized by diminished perfusion compared to healthy tissue — thereby initiating a localized inflammatory response and subsequent healing. We have demonstrated that RF treatment improves lung compliance and morphologic scores for emphysema in rats and improves exercise capacity in a murine model of emphysema [4, 5].
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".