Tumour-induced osteomalacia due to a rare intrathoracic phosphaturic mesenchymal tumour
Bibliographic record
Abstract
Phosphaturic mesenchymal tumours (PMTs) are rare neoplasms that secrete fibroblast growth factor 23 (FGF23), a hormone that disrupts phosphate homeostasis and induces tumour-induced osteomalacia (TIO). This condition causes hypophosphataemia, bone pain, fractures and musculoskeletal weakness. Due to the non-specific nature of these symptoms, TIO is often misdiagnosed with treatment delays. Surgical resection of PMTs is curative with rapid normalisation of serum phosphorus and full symptom resolution. PMTs are often located in the extremities and axial skeleton but can also occur in less common areas such as the intrathoracic region. We report a case of an intrathoracic PMT in a young woman who suffered for over 2 years without a diagnosis. The PMT was identified on CT, MRI and fluorodeoxyglucose-positron emission tomography and confirmed by histopathology. The tumour was excised via combined video-assisted thoracoscopic surgery and posterior thoracic resection. Within 6 months, the patient experienced complete symptom resolution and normalised serum levels.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.002 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.002 | 0.001 |
| Science and technology studies | 0.002 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.004 | 0.002 |
| Insufficient payload (model declined to judge) | 0.003 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".