THE SECRET OF C3 GLOMERULOPATHY IN A LUPUS PATIENT
Bibliographic record
Abstract
PV296 / #329 Case Report Poster Topic: AS22 - SLE Heterogeneity Introduction Objective Nephrological abnormalities in a patient with SLE are not exclusive to lupus nephropathy, but can reveal unexpected causes, as is the case in our patient. Case Presentation With Investigation Method Patient followed for an SLE whose histopathological study of the renal biopsy puncture objective an isolated C3 glomerulopathy. Results A 48 years old man followed for articular and hematological systemic lupus since the age of 19 years, presented persistent proteinuria with hematuria and consumption of complement. The histopathology of renal biopsy puncture,was in favor of a C3 glomerulopathy with active lesions.The exploration of this entity found a low third component of complement(C3:0.8g/l)and a monoclonal component of the IgG Lambda type. Glomerular filtration rate was normal (80 ml/mn).The diagnosis of monoclonal gammopathy of renal significance is more likely. Conclusion The SLE is a provider of nephropathy but the slightest atypia should alarm the clinician and the anatomical pathologist in order to broaden their diagnostic horizons Literature Review [1.] Ahmad SB. Adv Chronic Kidney Dis 2020;27(2):104-10. [2.] Heiderscheit AK. Am J Med Genet 2022;190(3):344-57. Discussion Conclusion: The SLE is a provider of nephropathy but the slightest atypia should alarm the clinician and the anatomical pathologist in order to broaden their diagnostic horizons
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.002 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.003 | 0.001 |
| Science and technology studies | 0.002 | 0.001 |
| Scholarly communication | 0.002 | 0.001 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.003 | 0.002 |
| Insufficient payload (model declined to judge) | 0.006 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".