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Record W4410731176 · doi:10.1186/s13075-025-03572-1

Functional work disability from the perspectives of persons with systemic lupus erythematosus: a qualitative thematic analysis

2025· article· en· W4410731176 on OpenAlexaffabout
Behdin Nowrouzi‐Kia, Aaron Howe, Anson Li, Jeremy Tan, Natalia Saade-Cleves, Kevon Jules, Malak Sadek, Ali Bani‐Fatemi, Antonio Aviña-Zubieta, Mary Fox, W. M. Shaw, Derek Haaland, Janet Pope, Paul R. Fortin, Kathleen Bingham, Christine Peschken, Jennifer Reynolds, Catherine Ivory, Dafna D. Gladman, Murray B. Urowitz, Jorge Sánchez‐Guerrero, Lily Siok Hoon Lim, Stephanie Keeling, Patti Katz, Mahta Kavkan, Dennisse Bonilla, Wils Nielsen, Zahi Touma

Bibliographic record

VenueArthritis Research & Therapy · 2025
Typearticle
Languageen
FieldMedicine
TopicSystemic Lupus Erythematosus Research
Canadian institutionsUniversity of AlbertaArthritis SocietyToronto Western HospitalCentre hospitalier de l'Université LavalLaurentian UniversityBarrie Urology GroupYork UniversityArthritis Research Centre of CanadaUniversity of ManitobaResearch CanadaUniversity of TorontoWestern UniversitySt Joseph's Health CareOttawa HospitalUniversity Health Network
Fundersnot available
KeywordsPsychosocialThematic analysisMedicineQuality of life (healthcare)Psychological interventionQualitative researchMental healthClinical psychologyPsychologyGerontologyPhysical therapyPsychiatryNursing

Abstract

fetched live from OpenAlex

BACKGROUND: Systemic lupus erythematosus (SLE) disease symptoms that can significantly restrict work ability and work participation resulting in reduced mental well-being. This study investigates the significant impact of work participation and disability on the mental wellbeing, health-related quality of life, and disease-related outcomes in individuals with SLE. METHODS: With the objective of creating an SLE-related functional profile rooted in work disability (WD) prevention, 46 SLE patients were purposively recruited from Canadian medical centres. Through semi-structured interviews guided by a WD prevention framework, factors associated with WD and lived experiences of SLE-related WD were qualitatively explored. Braun and Clarke's six-stage inductive thematic analysis was used to organize the data. RESULTS: Most participants experienced some form of work disability across their employment history related to their clinical manifestations of SLE, including hospitalizations, physical limitations, fatigue, and neurocognitive symptoms (e.g. brain fog). Thematic analysis revealed three key themes: (a) the influence of illness experience on work, (b) the stigmatization of illness disclosure, and (c) the availability of workplace resources/accommodations. Participants emphasized the desirability of work with reduced physical and mental demands, increased personal control, and workplace flexibility to prevent WD. CONCLUSION: The study underscores the need for a collaborative, multi-component, and multidisciplinary intervention targeting psychosocial and workplace factors to establish a goal-oriented preventative framework, potentially improving WD outcomes in SLE individuals.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.005
metaresearch head score (Gemma)0.001
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Qualitative · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.661
Threshold uncertainty score0.985

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0050.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0010.005
Science and technology studies0.0000.002
Scholarly communication0.0000.000
Open science0.0010.000
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.058
GPT teacher head0.381
Teacher spread0.323 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designQualitative
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations3
Published2025
Admission routes2
Has abstractyes

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