Metformin administration improves adverse outcomes in older adult burn patients: a single-centre cohort study
Bibliographic record
Abstract
This study assesses the safety and efficacy of metformin administration in older adult burn patients, a rapidly growing demographic with substantially poorer outcomes. This is a single-centre cohort study of older adults (≥60 years) admitted to a provincial burn center over 15 years. Clinical outcomes, laboratory measures, inflammatory markers, and adipose tissue single-nuclei RNA sequencing (SnRNA-seq) were compared among metformin-treated and non-treated controls. A total of 50 metformin-treated and 262 control older burn patients met the eligibility criteria. Despite pre-admission comorbidities, metformin-treated patients showed improved survival, no significant differences in the number of hypoglycemic episodes, a lower incidence of lactic acidosis, and reduced circulating levels of organ damage markers. SnRNA-Seq further revealed that metformin may exert its beneficial effects by local restoration of immune and inflammatory responses. In older burn patients, metformin was linked with improved outcomes and no adverse effects, underscoring its safety and efficacy in this population.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.000 | 0.001 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".