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Record W4410868944 · doi:10.1016/j.cdnut.2025.106946

Examination of the Current Evidence on Suboptimal Vitamin B12 Status and Neuropsychiatric Outcomes

2025· article· en· W4410868944 on OpenAlexaff
Samantha Yoo, Azita Montazeri, Derrick Bennett, Peizhan Chen, Susan J. Duthie, Natalie Jensen, Atipatsa Chiwanda Kaminga, Amanda J MacFarlane, Homero Martinez, Helene McNulty, Franco Momoli, Peter Mossey, Patrick Mullie, Ron Munger, Rajendra Parajuli, Monique Potvin Kent, Michele Rubini, Marjanne Senekal, Lindsey Sikora, Alain Stintzi, Evropi Τheodoratou, Hui Wang, Chittaranjan S. Yajnik, Ann Yaktine, Julian Little

Bibliographic record

VenueCurrent Developments in Nutrition · 2025
Typearticle
Languageen
FieldMedicine
TopicFolate and B Vitamins Research
Canadian institutionsNutrition InternationalHealth CanadaUniversity of Ottawa
Fundersnot available
KeywordsVitamin B12Current (fluid)MedicinePsychologyPsychiatryIntensive care medicineInternal medicinePhysics

Abstract

fetched live from OpenAlex

Objectives: Vitamin B12 is an important cofactor for DNA synthesis, myelin formation, and neurotransmitter metabolism. Vitamin B12 status has an established link to neurodegeneration and neuropathy, while associations to other neuropsychiatric conditions remain poorly understood. This study aimed to synthesize the evidence examining associations between suboptimal B12 status and neuropsychiatric outcomes using multiple measures of vitamin B12.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.010
metaresearch head score (Gemma)0.043
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Systematic review · Consensus signal: none
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.010
Threshold uncertainty score0.055

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0100.043
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0020.001
Bibliometrics0.0050.006
Science and technology studies0.0010.001
Scholarly communication0.0020.001
Open science0.0010.001
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0050.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.043
GPT teacher head0.369
Teacher spread0.327 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designSystematic review
Domainnot available
GenreReview

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2025
Admission routes1
Has abstractyes

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