Doxycycline Prophylaxis in Adolescent Patients Treated With <scp>MEK</scp> Inhibitors
Bibliographic record
Abstract
Mitogen-activated protein kinase inhibitors (MEKi) are used to treat various conditions, including plexiform neurofibromas, brain tumors, and cancers. Our study aimed to determine whether doxycycline prophylaxis could reduce the frequency and/or severity of acneiform eruptions and paronychia, common side effects of MEKi. Our retrospective study included data from 43 patients aged 12 to 18 years, who received MEKi treatment at the Hospital for Sick Children, Toronto, Canada, between 2010 and 2023. We found that while doxycycline prophylaxis did not significantly impact the frequency or severity of acneiform eruptions (based on CTCAE grading), it appeared to be associated with fewer MEKi discontinuations due to skin toxicities and decreased rates of paronychia.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".