Deposition of Ag/TMC Nanoparticles via MAPLE to Enhance the Mechanical and Antimicrobial Properties of Silicone Hydrogel
Bibliographic record
Abstract
High Resolution Image Download MS PowerPoint Slide Surface treatment of silicone hydrogels is essential for achieving suitable mechanical properties and high antimicrobial effectiveness. Incorporating biocompatible nanostructures into a silicone hydrogel can improve its mechanical strength and hydrophilicity. However, few studies have focused on directly depositing hybrid nanostructures onto a silicone hydrogel to enhance both its antimicrobial effectiveness and mechanical properties. Additionally, the impact of environmental conditions, such as hydration and physiological temperature, on the mechanical behavior of the nanostructure-deposited silicone hydrogel remains unclear. Herein, matrix-assisted pulsed laser evaporation (MAPLE) with a pulsed Nd:YAG laser at 532 nm has been applied to directly deposit silver/ N, N, N -trimethyl chitosan nanoparticles (Ag/TMC NPs) on the surface of silicone hydrogels. The effect of MAPLE irradiation time ( t ) on the deposition of organic–inorganic hybrid nanostructures on the silicone hydrogel has been studied. The Young’s modulus of silicone hydrogel deposited with Ag/TMC NPs increased from 76 to 139.38 kPa when t increases from 0 to 120 min. Meanwhile, the mechanical behavior of the silicone hydrogel deposited with Ag/TMC NPs was evaluated at different swelling states and environmental conditions, showing that the mechanical strength of the hydrogel strongly depends on hydration and temperature. On the other hand, the antimicrobial efficiency of silicone hydrogel deposited with Ag/TMC NPs against Escherichia coli ( E. coli ) and Staphylococcus aureus ( S. aureus ) increased by approximately 83.8 and 114.7%, respectively, when t increases from 0 to 120 min. In addition, NIH3T3 cells treated with a silicone hydrogel with/without the deposition of hybrid nanostructures were analyzed, indicating that the deposited nanostructures do not exhibit toxic effects on cells. Overall, this study demonstrates the versatility of MAPLE as a technique for depositing hybrid nanostructures onto silicone hydrogels to achieve improved mechanical and antimicrobial properties.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".