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Record W4411022406 · doi:10.1152/ajpregu.00285.2024

Evidence of intact resting but exercise-induced vascular impairment in congenital heart disease

2025· article· en· W4411022406 on OpenAlexafffund
M. Rafique Khan, Natasha G. Boyes, Adam M.S. Luchkanych, Thomas J. Jurrissen, Ibrahim Al-Mouaiad Al-Azem, Marta Erlandson, Kristi D. Wright, Charissa Pockett, T. Dylan Olver, Corey R. Tomczak

Bibliographic record

VenueAmerican Journal of Physiology-Regulatory, Integrative and Comparative Physiology · 2025
Typearticle
Languageen
FieldMedicine
TopicCongenital Heart Disease Studies
Canadian institutionsUniversity of ReginaUniversity of Saskatchewan
FundersNatural Sciences and Engineering Research Council of CanadaScottish Rite Charitable Foundation of CanadaHeart and Stroke Foundation of Canada
KeywordsReactive hyperemiaBrachial arteryMedicineForearmInternal medicineCardiologyIsometric exerciseVasodilationEndothelial dysfunctionArea under the curvePeripheralSurgeryBlood pressure

Abstract

fetched live from OpenAlex

Although young healthy control participants realize augmented brachial artery flow-mediated dilation following acute isometric handgrip exercise, young patients with congenital heart disease (CHD) fail to do so. Forearm microvascular function remains intact in congenital heart disease and is enhanced similarly to control participants following acute isometric handgrip exercise. Acute exercise may alter local regulatory mechanisms such that conduit artery endothelial-dependent vasodilation is not augmented, providing evidence of stress-induced vascular impairment in young patients with CHD.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.002
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.002
Threshold uncertainty score0.006

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0010.002
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0020.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.036
GPT teacher head0.337
Teacher spread0.301 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2025
Admission routes2
Has abstractyes

Explore more

Same venueAmerican Journal of Physiology-Regulatory, Integrative and Comparative Physiology→Same topicCongenital Heart Disease Studies→French-language works237,207→