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Record W4411035522 · doi:10.1101/2025.06.01.657249

Resistance to Atrial Fibrillation Domestication and Mitochondrial Dysfunction in Sheep: a potential key role of the TCA Cycle and mitochondrial redox state

2025· preprint· en· W4411035522 on OpenAlexafffund
Guido Caluori, Stanley Nattel, Benoı̂t Pinson, Patrice Naud, Bertrand Beauvoit, Stéphane Claverol, Fanny Vaillant, Sabine Charron, Florent Guilloteau, Virginie Loyer, Marion Constantin, Miruna Popa, А. Е. Белых, Andreas Haeberlin, Sylvain Ploux, Hassan Adam Mahamat, Rémi Dubois, Bastien Guillot, Philipp Krisai, Tsukasa Kamakura, Olivier Bernus, Pierre Jaı̈s, Pierre Dos Santos, Philippe Pasdois

Bibliographic record

VenuebioRxiv (Cold Spring Harbor Laboratory) · 2025
Typepreprint
Languageen
FieldMedicine
TopicCardiovascular Disease and Adiposity
Canadian institutionsHôpital Maisonneuve-RosemontUniversité de MontréalMontreal Heart Institute
FundersCanadian Institutes of Health ResearchFédération Française de CardiologieBiosense WebsterAgence Nationale de la RechercheInstitut National de la Santé et de la Recherche MédicaleDeutsche ForschungsgemeinschaftHeart and Stroke Foundation of CanadaCentre National de la Recherche ScientifiqueAbbott Laboratories
KeywordsDomesticationMitochondrionRedoxKey (lock)Resistance (ecology)BiologyInternal medicineCell biologyChemistryGeneticsMedicineEcology

Abstract

fetched live from OpenAlex

OpenAlex records an abstract for this work, but it could not be fetched just now.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.001
Threshold uncertainty score0.003

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.004
GPT teacher head0.205
Teacher spread0.201 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2025
Admission routes2
Has abstractyes

Explore more

Same venuebioRxiv (Cold Spring Harbor Laboratory)Same topicCardiovascular Disease and AdiposityFrench-language works237,207