Anti-inflammatory and immunomodulatory effects in vitro of polysaccharide- and polyphenol-rich extracts of white button and Turkey Tail mushrooms
Bibliographic record
Abstract
The health-promoting properties of mushrooms are associated with bioactive natural compounds such as polysaccharides and polyphenols. Anti-inflammatory and immunomodulatory properties of edible white button mushroom (WBM) and medicinal Turkey Tail mushroom (TT) were investigated. The results showed that polysaccharide-rich water extract of WBM and TT exhibit an anti-inflammatory effect in lipopolysaccharide-activated mouse liver cells by attenuating the interleukin (IL)6 and IL1β at mRNA and polysaccharide-rich water extract of WBM by attenuating IL6 and IL1β at protein levels. Also, polysaccharide-rich water and polyphenol-rich ethanolic extracts of WBM stimulated IgA secretion in the human plasma cells (H929 cells) in vitro which was partly mediated by the Signal Transducer and Activator of Transcription 3 (STAT3) pathway. These results suggest that WBM possesses potential anti-inflammatory and immune-enhancing properties and could be further assessed for use as a dietary supplement against inflammation and boosting immunity simultaneously.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".