Anorectic and anxiogenic actions of cocaine‐ and amphetamine‐regulated transcript in the lateral septum
Bibliographic record
Abstract
Abstract Cocaine‐ and amphetamine‐regulated transcript (CART) is produced in several brain regions including the hypothalamus where it is made in cells that also produce melanin‐concentrating hormone (MCH). CART‐expressing MCH cells densely innervate the lateral septum (LS), which integrates food‐ and mood‐related behaviours. However, while MCH typically promotes feeding and anxiolysis, CART suppresses feeding and promotes anxiogenesis. The LS is a target site of orexigenic MCH actions, but it is not known if the actions of CART converge or oppose that of MCH in the LS. We implanted a bilateral cannula over the lateral or medial LS of male and female wildtype mice and infused vehicle, CART 55–102 , MCH, or CART + MCH. We then assessed the intake of a standard chow diet or palatable high sugar diet over 4 h, as well as anxiety‐like behaviour via the open‐field test. In both male and female mice, intra‐LS CART infusion alone did not produce anorexigenic effects. However, CART infusion diminished MCH‐mediated feeding, especially via the lateral LS. By contrast, intra‐LS CART infusion reduced time spent in the centre of an open field in male but not female mice. Our findings indicated that CART elicited anorectic effects in the presence of MCH, but CART independently produced anxiogenic effects. These outcomes suggested that putative CART and MCH co‐release from MCH neurons may provide biphasic regulation of feeding and anxiety.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".