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Record W4411057714 · doi:10.58931/cpct.2025.3140

Menopause Hormone Therapy in 2025

2025· article· en· W4411057714 on OpenAlexaffabout
Susan Goldstein

Bibliographic record

VenueCanadian Primary Care Today · 2025
Typearticle
Languageen
FieldMedicine
TopicMenopause: Health Impacts and Treatments
Canadian institutionsUniversity of Toronto
Fundersnot available
KeywordsMenopauseHormone therapyMedicineHormoneHormone replacement therapy (female-to-male)GynecologyInternal medicineBreast cancerCancerTestosterone (patch)

Abstract

fetched live from OpenAlex

Menopause is, in fact, a single day officially marked one year after the cessation of menses. It is followed by post menopause which can last for half of a women’s adult life! Menopause typically occurs between the ages of 46 and 52 years with an average age of 51. It signifies the end of reproductive function, and is marked by fluctuating and declining hormone levels, which can lead to a range of often distressing symptoms. The perimenopause is the transition phase that precedes menopause, lasting up to 10 years. For many women, menopausal symptoms may first appear later in the perimenopause. While we use the term “women”, guidance applies to all patients who experience menopause, even if they do not identify as a woman. When people use the term “menopause” they are usually referring to the “climacteric”, a period which includes the perimenopause, menopause, and early post menopause stages. In Canada, over 2.5 million women are between the ages of 45 and 55, and up to 80% of them will experience menopause-related symptoms. There are now over 30 validated symptoms of menopause, some of which can have a significant impact on function and quality of life. A recent study by the Menopause Foundation of Canada reported that up to 10% of women will leave the workforce due to unmanaged menopausal symptoms. The most impactful symptoms of menopause include vasomotor symptoms (VMS) which include hot flashes and night sweats, sleep and mood disturbances, memory issues, muscle and joint pains, and symptoms of the Genitourinary Syndrome of Menopause (GSM) such as vaginal dryness, bladder issues, and sexual dysfunction. Recent evidence has shown that frequent or severe menopausal vasomotor symptoms are linked to a higher risk for illnesses including cardiovascular disease and diabetes.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.002
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: Not applicable
GenreCandidate signal: Review · Consensus signal: none
Teacher disagreement score0.113
Threshold uncertainty score0.379

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0010.002
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0010.001
Science and technology studies0.0010.000
Scholarly communication0.0020.001
Open science0.0010.001
Research integrity0.0020.002
Insufficient payload (model declined to judge)0.1130.056

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.018
GPT teacher head0.289
Teacher spread0.272 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designNot applicable
Domainnot available
GenreReview

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations1
Published2025
Admission routes2
Has abstractyes

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